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Cyclodextrin inclusion complexes improving antibacterial drug profiles: an update systematic review
Anamaria M Santos1, José Acn Júnior2, Silvia Vs Cézar3
1Postgraduate Program in Health Sciences, Federal University of Sergipe, Aracaju, 49060-100, Sergipe, Brazil.
Future Microbiology
|November 1, 2023
Summary
Cyclodextrins significantly enhance antibacterial drugs by improving solubility and bioavailability. These drug delivery systems boost the effectiveness of existing antibiotics and novel compounds against bacteria.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Medicinal Chemistry
Background:
- Antibacterial agents often face challenges with poor physicochemical properties like low solubility and stability.
- Improving these characteristics is crucial for enhancing therapeutic efficacy and overcoming drug resistance.
- Cyclodextrins are versatile host molecules with potential for drug formulation enhancement.
Purpose of the Study:
- To review experimental models utilizing cyclodextrins for improving antibacterial drugs.
- To assess the impact of cyclodextrins on the physicochemical and biological properties of antibacterial agents.
Main Methods:
- A systematic literature search was conducted up to October 2022.
- Databases searched included PubMed, Scopus, and Embase.
- Keywords used were 'cyclodextrins' and 'antibacterial agents' in titles or abstracts.
Main Results:
- A total of 27 studies were selected from 1580 identified articles.
- Inclusion complexes formed with cyclodextrins demonstrated significantly improved antibacterial effects.
- Cyclodextrins successfully enhanced the therapeutic potential of both existing and novel antibacterial compounds.
Conclusions:
- Cyclodextrins serve as effective drug delivery vehicles for antibacterial agents.
- These compounds notably improve antibiotic solubility, stability, and bioavailability.
- Enhanced properties translate to a significant increase in overall antibacterial activity.
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