Premature chromosome condensation in human cervical carcinoma

Premature chromosome condensation was observed in 22 of 150 cases (15%) of cervical cancers studied with G-banding. The percentage of premature chromosome condensation in the tumors ranged from 1.5% to 8.9%. Premature chromosome condensation was present in greater frequency (16 of 22 cases) in tumors showing hyperdiploidy, suggesting that this could be a major mechanism of induction of polyploidy in addition to other operative mechanisms, such as endomitosis and endoreduplication. No relationship, either with the disease stage or prognosis, was evident.