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Updated: Jul 12, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Glioma and post-translational modifications: A complex relationship
Tomasz Pienkowski1, Tomasz Kowalczyk2, Dominik Cysewski1
1Clinical Research Centre, Medical University of Bialystok, M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.
Post-translational modifications (PTMs) alter protein function and can lead to new proteoforms. Understanding PTMs and their crosstalk in glioma offers new therapeutic and diagnostic biomarker opportunities in PTMomics.
Area of Science:
- Biochemistry
- Molecular Biology
- Cancer Research
Background:
- Post-translational modifications (PTMs) are crucial covalent processes altering protein function and activity.
- PTMs involve proteolytic cleavage or addition of groups like phosphoryl, methyl, glycosyl, or acetyl to amino acid residues.
- PTM crosstalk can modify protein functionality and structure, generating novel proteoforms.
Purpose of the Study:
- To review experimentally confirmed PTMs and their crosstalk in glioma.
- To highlight the potential of PTMs and proteoforms as therapeutic targets and biomarkers in glioma.
- To introduce emerging opportunities within the PTMomics field for glioma research.
Main Methods:
- Literature review of experimentally confirmed PTMs.
- Analysis of PTM crosstalk mechanisms.
- Focus on PTMs and proteoforms relevant to glioma.
Main Results:
- PTMs significantly impact protein function, structure, and the emergence of proteoforms.
- PTM crosstalk presents complex regulatory networks affecting cellular homeostasis.
- Alterations in PTMs are linked to cancer hallmarks, including glioma.
Conclusions:
- Cataloging PTMs and proteoforms provides novel therapeutic targets for glioma.
- PTMs offer opportunities for discovering discriminatory biomarkers for disease diagnostics.
- The PTMomics field holds significant promise for advancing glioma research and treatment.
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