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Injectable tissue prosthesis for instantaneous closed-loop rehabilitation.

Subin Jin1,2, Heewon Choi2,3, Duhwan Seong2,3

  • 1Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.

Nature
|November 2, 2023
PubMed
Summary
This summary is machine-generated.

Researchers developed an injectable hydrogel prosthesis that enables bidirectional electrical conduction for neuromuscular applications. This new material supports robot-assisted rehabilitation and accelerates tissue repair in muscle injuries.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Neuroprosthetics

Background:

  • Soft electroactive hydrogels offer promising properties for tissue-like prosthetic materials, including suitable mechanical modulus and electrical conductivity.
  • Current bioelectronic prosthetic devices are typically patch-type, limiting their application on irregular or deep tissue surfaces.

Purpose of the Study:

  • To develop an injectable tissue prosthesis with instantaneous bidirectional electrical conduction for neuromuscular applications.
  • To overcome the limitations of current patch-type bioelectronic devices.

Main Methods:

  • Fabrication of a biocompatible hydrogel using phenylborate-mediated crosslinking with biphenyl bonds and gold nanoparticles.
  • In situ formation of conductive gold nanoparticles via cross-coupling reactions.
  • Demonstration of closed-loop robot-assisted rehabilitation in rats with severe muscle injury.

Main Results:

  • The injectable prosthesis demonstrated instantaneous bidirectional electrical conduction in the neuromuscular system.
  • Successful application of closed-loop robot-assisted rehabilitation using the injectable material in an animal model.
  • Evidence of accelerated tissue repair in the later stages of muscle injury.

Conclusions:

  • The novel injectable hydrogel prosthesis offers a new solution for neuromuscular applications, overcoming limitations of existing patch-type devices.
  • The material facilitates effective robot-assisted rehabilitation and promotes tissue regeneration.