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If the Patient Does Not Take the Medication, It Will Not Work
Iván Sánchez Fernández1, Adriana Ulate-Campos2
1Boston Children's Hospital, Harvard Medical School, Boston, MA.
Seminars in Pediatric Neurology
|November 2, 2023
Summary
Antiepileptic drugs (AEDs) can worsen behavior and cognition in children with epilepsy, even when seizures are controlled. This review helps clinicians choose AEDs with better cognitive and behavioral profiles for pediatric patients.
Area of Science:
- Neurology
- Pediatrics
- Pharmacology
Background:
- Epilepsy affects 20-30% of children, with seizures negatively impacting behavior and cognition.
- Antiepileptic drugs (AEDs), while necessary for seizure control, can also contribute to cognitive and behavioral deficits.
- The impact of AEDs on pediatric cognitive and behavioral health is often underestimated in medical literature.
Approach:
- This review synthesizes existing literature on the cognitive and behavioral effects of AEDs in children.
- It aims to provide a comprehensive overview for healthcare professionals.
- The objective is to guide the selection of AEDs with favorable neurodevelopmental profiles.
Key Points:
- Seizures themselves impair cognitive and behavioral function in pediatric epilepsy.
- AEDs are a significant factor contributing to these impairments.
- Specific AEDs may have varying effects on a child's behavior and cognition.
Conclusions:
- Pediatricians and pediatric neurologists need to consider the cognitive and behavioral side effects of AEDs.
- Careful selection of AEDs is crucial to minimize negative impacts on development.
- Further emphasis on AED-related neurodevelopmental effects is warranted in clinical practice and research.
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