Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
The Thyroid Gland01:23

The Thyroid Gland

3.9K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.9K
Aging01:26

Aging

59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
59
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Bone Disorders01:29

Bone Disorders

3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Levothyroxine treatment response of cardiometabolic biomarkers in older adults with subclinical hypothyroidism.

The Journal of clinical endocrinology and metabolism·2026
Same author

Thyroid dysfunction in ageing populations.

Endocrine connections·2025
Same author

Robust Metabolomic Age Prediction Based on a Wide Selection of Metabolites.

The journals of gerontology. Series A, Biological sciences and medical sciences·2025
Same author

Maternal Thyroid Function in Early Pregnancy and Offspring School Performance and Neurodevelopmental Disorders.

The Journal of clinical endocrinology and metabolism·2024
Same author

No evidence linking sleep traits with white blood cell counts: Multivariable-adjusted and Mendelian randomization analyses.

European journal of clinical investigation·2024
Same author

Antioxidant Supplementation in Oxidative Stress-Related Diseases: What Have We Learned from Studies on Alpha-Tocopherol?

Antioxidants (Basel, Switzerland)·2022

Related Experiment Video

Updated: Jul 11, 2025

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

3.7K

The ageing thyroid: implications for longevity and patient care.

Diana van Heemst1

  • 1Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands. d.van_heemst@lumc.nl.

Nature Reviews. Endocrinology
|November 4, 2023
PubMed
Summary

Thyroid hormone action is crucial for tissue repair and homeostasis, with age-related changes potentially impacting health. This review examines altered thyroid status in aging and its link to longevity and disease.

More Related Videos

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.6K
A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.4K

Related Experiment Videos

Last Updated: Jul 11, 2025

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy
05:12

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

3.7K
Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence
12:08

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

46.6K
A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery
04:42

A Personalized 3D-Printed Model for Preoperative Evaluation in Thyroid Surgery

Published on: February 17, 2023

1.4K

Area of Science:

  • Endocrinology and Gerontology
  • Molecular Biology and Aging

Background:

  • Thyroid hormones regulate critical physiological processes including metabolism, growth, and development.
  • Age-related dysregulation of thyroid hormone action is increasingly linked to tissue homeostasis disruption and age-related diseases.
  • Circulating thyroid-stimulating hormone levels tend to rise with age, particularly in individuals over 80.

Purpose of the Study:

  • To review biomedical findings on the role of precise thyroid hormone action in tissue maintenance and repair.
  • To discuss the causes and consequences of altered thyroid status in aging and its association with longevity.
  • To evaluate clinical trial results on thyroid hormone replacement therapy for older adults with subclinical hypothyroidism.

Main Methods:

  • Review of biomedical literature focusing on thyroid hormone action and aging.
  • Analysis of age-related trends in thyroid-stimulating hormone concentrations.
  • Examination of randomized clinical trials on thyroid hormone replacement in elderly populations.

Main Results:

  • Age-associated increases in thyroid-stimulating hormone are observed in healthy older adults.
  • Subclinical hypothyroidism (elevated TSH, normal thyroid hormone levels) affects 5-20% of adults over 65.
  • Clinical trial data on thyroid hormone replacement in older adults with mild subclinical hypothyroidism are under review.

Conclusions:

  • Precise thyroid hormone regulation is vital for local tissue maintenance and repair, with age-related changes impacting homeostasis.
  • Altered thyroid status in aging, including subclinical hypothyroidism, warrants further investigation regarding its impact on health and longevity.
  • Findings from clinical trials will inform screening and treatment strategies for subclinical hypothyroidism in older adults.