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Related Experiment Video

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Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

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Published on: May 31, 2021

Epigenetics insights from perceived facial aging.

Klemo Vladimir^1,2, Marija Majda Perišić^1,3, Mario Štorga^1,3

¹LifeNome Inc., New York, 10018, NY, USA.

Clinical Epigenetics

|November 4, 2023

Summary

This study identifies blood methylation markers that causally influence how old your face looks. These findings could lead to new anti-aging strategies targeting the root causes of skin aging.

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Area of Science:

Genetics and Epigenetics
Dermatology
Aging Research

Background:

Facial aging is a visible indicator of biological aging.
Epigenetic clocks estimate biological age using methylation markers.
The causal role of epigenetic biomarkers in facial aging remains unclear.

Purpose of the Study:

To investigate the causal relationship between blood methylation markers and perceived facial aging.
To identify specific epigenetic biomarkers (CpGs) that drive or protect against facial aging.
To explore the potential of blood methylation markers for quantifying skin aging and developing anti-aging interventions.

Main Methods:

Integration of genome-wide association studies (GWAS) for perceived facial aging and epigenome-wide association studies (EWAS) for blood CpGs.
Application of Mendelian randomization (MR) to infer causality between CpGs and facial aging.
Analysis of candidate causal CpGs for overlap with existing epigenetic clocks and their association with skin aging-related genes.

Main Results:

Hundreds of putative CpGs causally linked to perceived facial aging were identified.
Both aging-accelerating and aging-slowing methylation markers were found.
Candidate causal CpGs showed limited overlap with known epigenetic clocks but targeted genes involved in skin pigmentation, elastin, and collagen.

Conclusions:

Blood methylation markers reflect underlying facial aging processes.
Identified CpGs offer potential as biomarkers for skin aging.
These findings pave the way for developing targeted anti-aging solutions addressing the root causes of skin aging.