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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
359

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Soft and Flexible Bioelectronic Micro-Systems for Electronically Controlled Drug Delivery.

Massimo Mariello1, Ismail Eş1, Christopher M Proctor1

  • 1Department of Engineering Science, Institute of Biomedical Engineering (IBME), University of Oxford, Oxford, OX3 7DQ, UK.

Advanced Healthcare Materials
|November 4, 2023
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Summary
This summary is machine-generated.

Electronically controlled drug delivery (ECDD) offers precise, adaptable treatment by overcoming biological barriers. This technology utilizes soft, flexible bioelectronic systems for improved medical device effectiveness and patient outcomes.

Keywords:
bioelectronicsdrug deliveryelectronic controlelectrophoresisflexibilityimplantable devicesingestible devicesmicro‐systemssoft bioelectronic systemswearable devices

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Pharmacology

Background:

  • Targeted drug delivery aims to enhance therapeutic efficacy and minimize systemic toxicity.
  • Current drug delivery systems face challenges in biocompatibility, tissue integration, and overcoming biological barriers.
  • Advancements in precision medicine necessitate novel materials and approaches for controlled therapeutic administration.

Purpose of the Study:

  • To review recent breakthroughs in soft, flexible bioelectronic micro-systems for electronically controlled drug delivery (ECDD).
  • To provide an overview of ECDD operational modes, materials, electronic interfaces, and characterization techniques.
  • To discuss the applications, future prospects, and challenges of ECDD in medical devices.

Main Methods:

  • Review of recent literature on soft, flexible, and adaptable bioelectronic micro-systems for ECDD.
  • Analysis of operational modes, materials engineering strategies, and electronic interfaces.
  • Exploration of characterization techniques and applications in wearable, ingestible, and implantable devices.

Main Results:

  • Emergence of ECDD as a precise method for calibrated drug delivery with spatial and temporal control.
  • Development of soft, flexible bioelectronic micro-systems enabling adaptable drug release.
  • Identification of key materials, interfaces, and characterization methods crucial for ECDD system development.

Conclusions:

  • ECDD systems represent a significant advancement in precision medicine, offering enhanced control over drug administration.
  • Soft, flexible bioelectronic micro-systems are pivotal for developing next-generation ECDD devices.
  • Further research is needed to address challenges and fully realize the potential of ECDD in clinical applications.