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Systemic Therapy for Lichen Sclerosus: A Systematic Review.
Abby Hargis1, Madeline Ngo2, Christina N Kraus3
1Eastern Virginia Medical School, Norfolk, VA.
Journal of Lower Genital Tract Disease
|November 4, 2023
Summary
Systemic therapies show promise for lichen sclerosus (LS) treatment, with oral retinoids, methotrexate, and systemic steroids demonstrating significant improvement in anogenital and extragenital cases. Further research is needed to compare treatment efficacy.
Area of Science:
- Dermatology
- Internal Medicine
- Pharmacology
Background:
- Lichen sclerosus (LS) is a chronic inflammatory skin condition primarily affecting anogenital areas, with potential for extragenital involvement.
- Topical immunosuppression is the standard treatment for anogenital LS, but systemic therapies are considered for refractory or severe cases.
- Current guidelines for systemic LS therapy are lacking.
Conclusions:
- Multiple systemic therapies have demonstrated success in treating both genital and extragenital lichen sclerosus.
- Further research is essential to establish definitive treatment outcomes and compare the efficacy of different systemic LS therapies.
- The review highlights the need for evidence-based guidelines for systemic LS management.
