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Related Concept Videos

Aging01:26

Aging

59
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Updated: Jul 11, 2025

Techniques to Induce and Quantify Cellular Senescence
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Lifestyle interventions to delay senescence.

Jan Martel1, David M Ojcius2, John D Young3

  • 1Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan.

Biomedical Journal
|November 4, 2023
PubMed
Summary

Lifestyle interventions like exercise and diet can reduce cellular senescence, a key driver of aging and chronic diseases. These strategies offer a natural approach to combat age-related inflammation and promote health.

Keywords:
Caloric restrictionExerciseMetforminNutritionPhytochemicalsSenescence

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Area of Science:

  • Gerontology and cellular biology.
  • Investigating the biological mechanisms of aging.

Background:

  • Cellular senescence, a state of irreversible cell cycle arrest, is linked to increased inflammation and chronic diseases.
  • Senolytics and senomorphics show promise, but lifestyle interventions are under-explored.

Purpose of the Study:

  • To review the impact of various lifestyle interventions on cellular senescence.
  • To highlight natural approaches for mitigating age-related decline.

Main Methods:

  • Literature review of studies on exercise, nutrition, caloric restriction, intermittent fasting, phytochemicals, prebiotics, probiotics, and sleep.
  • Analysis of effects in model organisms and human subjects.

Main Results:

  • Multiple lifestyle factors demonstrably reduce cellular senescence and associated inflammation.
  • These interventions show potential in delaying age-related disease development.

Conclusions:

  • Lifestyle interventions offer a viable strategy to manage cellular senescence and inflammation.
  • Integrating these practices can promote healthy aging and reduce chronic disease burden.