Gender differences in central serous chorioretinopathy based on the new multimodal imaging classification

Area of Science:

• Ophthalmology
• Retinal Diseases
• Medical Imaging

Background:

• Central serous chorioretinopathy (CSCR) is a condition affecting vision.
• Understanding gender-specific differences in CSCR is crucial for tailored treatment approaches.
• Multimodal imaging offers advanced diagnostic capabilities for retinal conditions.

Purpose of the Study:

• To investigate gender-specific variations in central serous chorioretinopathy (CSCR).
• To analyze these differences using a novel multimodal imaging classification system.
• To correlate imaging findings with clinical outcomes and patient demographics.

Main Methods:

• Retrospective, multicentric, longitudinal, observational study.
• Inclusion of patients diagnosed with unilateral or bilateral CSCR.
• Analysis of visual acuity, CSCR complexity (Simple vs. Complex), choroidal neovascularization (CNVM), and recurrence rates.
• Multivariable regression analysis to identify predictors of visual acuity outcomes.

Main Results:

• Complex CSCR was more prevalent in males (85.2%) than females (61.8%) (p=0.005).
• Recurrence (p=0.03) and bilateral presentation (p=0.03) were significantly higher in males.
• Choroidal neovascularization (CNVM) was more common in females (p=0.23).
• Simple CSCR, good baseline visual acuity, and prior steroid use were associated with a reduced need for treatment.

Conclusions:

• Males with CSCR are more likely to have complex disease and experience recurrence.
• Females with CSCR exhibit a higher incidence of choroidal neovascularization (CNVM).
• These findings highlight significant gender-based differences in the presentation and progression of CSCR.