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Elevated matrix metalloproteinase‑9 expression is associated with COVID‑19 severity: A meta‑analysis

Ling Ding1,2, Haipeng Guo1,2, Chao Zhang1,2

  • 1Department of Laboratory Medicine, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, P.R. China.

Experimental and Therapeutic Medicine
|November 6, 2023
PubMed

Insights

Serum matrix metalloproteinase-9 (MMP-9) levels are elevated in severe COVID-19 cases and associated with complications like ARDS. Higher MMP-9 indicates increased disease severity and potential therapeutic targets for COVID-19 patients.

Area of Science:

  • Biochemistry
  • Immunology
  • Infectious Diseases

Background:

  • Coronavirus Disease 2019 (COVID-19) poses significant global health challenges.
  • Understanding biomarkers for COVID-19 severity is crucial for patient management.
  • Matrix metalloproteinase-9 (MMP-9) is implicated in inflammatory processes.

Purpose of the Study:

  • To evaluate the clinical significance of serum MMP-9 levels in COVID-19 patients.
  • To correlate MMP-9 levels with disease severity and patient outcomes.

Main Methods:

  • A meta-analysis of 12 studies involving 2,062 COVID-19 patients.
  • Searched databases including PubMed, Web of Science, EMBASE, Cochrane, WANFANG, and CNKI.
  • Compared serum MMP-9 levels across different patient subgroups (severe vs. non-severe, ARDS vs. non-ARDS, survivors vs. non-survivors, etc.).

Main Results:

  • Serum MMP-9 levels were significantly higher in severe COVID-19 patients compared to non-severe cases.
  • Elevated MMP-9 levels were observed in patients with Acute Respiratory Distress Syndrome (ARDS).
  • Higher MMP-9 levels were also noted in patients with neurological syndromes and obese diabetic patients.

Conclusions:

  • Serum MMP-9 levels are significantly associated with COVID-19 severity.
  • MMP-9 may serve as a potential biomarker for predicting COVID-19 progression.
  • Targeting MMP-9 could be a therapeutic strategy for improving COVID-19 patient prognosis.

Keywords:
COVID-19MMP-9comorbiditymortalityseverity

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