Citric Acid Catalyst-Assisted Bioactive Glass with Hydrogen Peroxide for In Vitro Bioactivity and Biodegradability...

Area of Science:

• Biomaterials Science
• Materials Chemistry
• Sol-Gel Synthesis

Background:

• Conventional surfactants used in bioactive glass (BG) production can be environmentally harmful.
• Developing sustainable and effective pore-forming agents is crucial for advanced biomaterial fabrication.

Purpose of the Study:

• To investigate the use of hydrogen peroxide (H2O2) as a carbon-free pore-forming agent in BG synthesis.
• To evaluate the impact of varying H2O2 concentrations on BG properties and performance.
• To compare H2O2-treated BG with untreated BG for biomedical applications.

Main Methods:

• Bioactive glass (BG) specimens were prepared using a sol-gel method.
• H2O2 treatment was applied at concentrations of 1M, 2M, and 3M.
• Characterization involved XRD, SEM, FTIR, EDS, and BET analysis.
• In vitro bioactivity and biodegradability were assessed in simulated body fluid (SBF).

Main Results:

• The 2 M H2O2-treated BG exhibited the highest specific surface area (SSA) of 189.55 cc/g.
• Increased H2O2 concentration positively influenced pore structure and surface area.
• Enhanced in vitro bioactivity and biodegradability were observed in the 2 M H2O2-treated BG samples.

Conclusions:

• Hydrogen peroxide (H2O2) is an effective, environmentally friendly pore-forming agent for bioactive glass (BG) synthesis.
• Optimized H2O2 treatment significantly improves BG's surface area, bioactivity, and biodegradability.
• This approach offers a promising route for developing advanced BG materials for regenerative medicine.