Effect of transducer position on ultrasonic backscatter measurements of cancellous bone

Ultrasonic backscatter techniques are being developed to detect changes in bone caused by osteoporosis and other diseases. Backscatter measurements performed at peripheral skeletal sites such as the heel may place the interrogated region of bone tissue in the acoustic near field of the transducer. The purpose of this study is to investigate how measurements in the near field affect backscatter parameters used for ultrasonic bone assessment. Ultrasonic measurements were performed in a water tank using a planar 2.25 MHz transducer. Signals were acquired for five transducer-specimen distances: N/4, N/2, 3 N/4, N, and 5 N/4, where N is the near-field distance, a location that represents the transition from the near field to far field. Five backscatter parameters previously identified as potentially useful for ultrasonic bone assessment purposes were measured: apparent integrated backscatter, frequency slope of apparent backscatter (FSAB), frequency intercept of apparent backscatter, normalized mean of the backscatter difference, and backscatter amplitude decay constant. All five parameters depended on transducer-specimen distance to varying degrees with FSAB exhibiting the greatest dependence on distance. These results suggest that laboratory studies of bone should evaluate the performance of backscatter parameters using transducer-specimen distances that may be encountered clinically including distances where the ultrasonically interrogated region is in the near field of the transducer.