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Related Concept Videos

Peptide Identification Using Tandem Mass Spectrometry01:33

Peptide Identification Using Tandem Mass Spectrometry

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Tandem mass spectrometry, also known as MS/MS or MS2, is an analytical technique that employs two mass analyzers. Essentially it is a series of mass spectrometers that helps isolate a particular biomolecule and then helps study its chemical properties.
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...
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Neutron Crystallography Data Collection and Processing for Modelling Hydrogen Atoms in Protein Structures
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Neutron reflection and scattering in characterising peptide assemblies.

Xuzhi Hu1, Mingrui Liao2, Ke Ding2

  • 1Biological Physics Group, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.; Lanzhou Institute of Chemical Physics, Tianshui Middle Road, Lanzhou 730000, Gansu, China.

Advances in Colloid and Interface Science
|November 6, 2023
PubMed
Summary

Neutron scattering techniques like small angle neutron scattering (SANS) and neutron reflection (NR) effectively characterize peptide self-assembly. These methods reveal structural changes in response to stimuli, aiding biopharmaceutical development.

Keywords:
Antimicrobial peptidesCOVID-19Interfacial assemblyNRNanostructuresPeptide amphiphilesSANSSelf-assembly

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Area of Science:

  • Biophysics
  • Materials Science
  • Nanotechnology

Background:

  • Self-assembly of de novo designed peptides forms nanostructures with medical and technological applications.
  • Characterizing dynamic self-assembly processes and responses to stimuli in bioinspired supramolecular nanostructures is challenging.

Approach:

  • This review introduces neutron scattering techniques, specifically small angle neutron scattering (SANS) and neutron reflection (NR).
  • It covers basic theory, experimental setups, and data analysis for SANS and NR.
  • Applications in characterizing interfacial and solution self-assemblies of peptides and proteins are discussed.

Key Points:

  • SANS and NR are advantageous and complementary techniques for tracing structural changes during self-assembly.
  • These methods are effective in determining morphological features, including size and shape transitions of self-assembled peptides.
  • They reveal how sequence changes or environmental stimuli influence peptide self-assembly.

Conclusions:

  • Neutron scattering uniquely unravels interactive processes in peptide and protein self-assembly.
  • SANS and NR demonstrate potential in developing novel peptide and protein biopharmaceuticals for diseases involving membrane interactions.