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Nanomaterial surface modification toolkit: Principles, components, recipes, and applications.

Sümeyra Vural Kaymaz1, Hediyeh Malekzadsani Nobar2, Hasan Sarıgül2

  • 1Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, Turkey; SUNUM Nanotechnology Research and Application Centre, Sabanci University, Istanbul 34956, Turkey.

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Surface functionalization of nanostructures enhances biotechnology applications like biosensors and drug delivery. This review details modification strategies and their impact on nano-bio interfaces for diverse applications.

Keywords:
BiomodificationBiosensorsEnvironmental monitoringNanoparticlesPoint of care devicesSurface modification

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Area of Science:

  • Biotechnology and Nanotechnology Interface
  • Materials Science and Surface Chemistry

Background:

  • Surface-functionalized nanostructures are crucial for advanced biotechnology.
  • Nanostructure modification enables precise targeting and improves application performance.

Purpose of the Study:

  • To review widely practiced surface modification strategies for nanostructures.
  • To explore the application landscape of the nano-bio interface in key domains.
  • To provide a comprehensive overview for researchers in nanotechnology and biotechnology.

Main Methods:

  • Elucidation of various surface modification techniques: click chemistry, cross-coupling, silanization, etc.
  • Analysis of protein and DNA-based methodologies for nanostructure functionalization.
  • Review of recent literature (2018-2023) on nano-bio interface applications.

Main Results:

  • Detailed overview of diverse chemical strategies for nanostructure surface functionalization.
  • Highlighting prominent studies in therapeutics, biosensing, environmental monitoring, and point-of-care technologies.
  • Demonstration of how surface modification impacts nano-bio interface applications.

Conclusions:

  • Surface modification is key to unlocking the potential of nanostructures in biotechnology.
  • The review serves as a handbook for innovations in nanotechnology and biotechnology.
  • Future research directions are suggested for the nano-bio interface.