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Noncoding RNAs: Versatile regulators of endothelial dysfunction.

Xiong Piao1, Lie Ma1, Qinqi Xu1

  • 1Cardiovascular Surgery, Yanbian University Hospital, Yanji 133000, China.

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|November 6, 2023
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Summary
This summary is machine-generated.

Noncoding RNAs regulate endothelial dysfunction in atherosclerosis. Understanding these interactions offers new therapeutic strategies for this chronic inflammatory disease.

Keywords:
AtherosclerosisEndothelial dysfunctionNoncoding RNAs

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Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Atherosclerosis involves endothelial dysfunction (ECD), a chronic inflammatory process.
  • Noncoding RNAs (ncRNAs) are key regulators of cellular processes in ECD.
  • ECD contributes to plaque formation in arterial walls.

Purpose of the Study:

  • To review the regulatory roles of ncRNAs in endothelial dysfunction during atherosclerosis.
  • To highlight specific ncRNAs, their targets, and mechanisms in ECD pathogenesis.
  • To explore interactions between ncRNAs and current atherosclerosis therapeutics.

Main Methods:

  • Literature review of noncoding RNAs in atherosclerosis and endothelial dysfunction.
  • Analysis of microRNAs, long noncoding RNAs, and circular RNAs.
  • Examination of therapeutic targets and their ncRNA interactions.

Main Results:

  • ncRNAs critically modulate inflammation, pyroptosis, migration, proliferation, apoptosis, oxidative stress, and angiogenesis in ECD.
  • Specific ncRNAs and their target genes implicated in ECD pathogenesis are identified.
  • Interactions between existing atherosclerosis treatments and ncRNAs are discussed.

Conclusions:

  • ncRNAs are versatile regulators of endothelial dysfunction in atherosclerosis.
  • Understanding ncRNA networks in ECD can lead to novel therapeutic strategies.
  • Targeting ncRNAs presents a promising avenue for combating atherosclerosis.