Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Charge-Engineered COFs for Biointegrated Memristor Nerves.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

A hollow MnO<sub>2</sub> nanozymes empowered injectable hydrogel for intrauterine adhesion therapy by alleviating oxidative stress and promoting endometrial repair.

Biomaterials science·2026

Same author

Post-stroke rehabilitative mechanisms in individualized fatigue level-controlled treadmill training in rats.

Neural regeneration research·2026

Same author

AutoSimTTF: a fully automatic pipeline for personalized electric field simulation and treatment planning of tumor treating fields.

Physics in medicine and biology·2026

Same author

RETRACTED ARTICLE: Implantable neural probes with monolithically integrated CNTFET arrays for multimodal monitoring.

Nature communications·2025

Same author

Conformal PEDOT:PSS Microelectrode Arrays with Controllable Doping Level and High Structural Order for Electrocorticogram Recording.

ACS applied materials & interfaces·2025

Same journal

Expanding CAM Models: In Vivo PET/CT Imaging of Cancer Xenografts on the Ostrich CAM.

ACS applied bio materials·2026

Same journal

Photothermal Pulse Output-Nanomachines for Enhanced Cuproptosis in Tumor Cells.

ACS applied bio materials·2026

Same journal

TENG-Driven Electrotherapy: A Self-Powered Approach to Inducing Cancer Cell Apoptosis.

ACS applied bio materials·2026

Same journal

Heparinized Elastomeric Nanofibrillar Grafts: Mechanically Tunable, Cell-Supportive, and Thromboresistant Vascular Substitutes.

ACS applied bio materials·2026

Same journal

Adenosine Triphosphate-Coated Gold Nanoclusters as Evolutionary Adjuvants Suppress <i>fusA</i>-Mediated Antibiotic Resistance Evolution.

ACS applied bio materials·2026

Same journal

Localized Nitric Oxide Release from a Ciprofloxacin Hybrid Conjugate Enables Potent Disruption of Gram-Positive and Gram-Negative Biofilms.

ACS applied bio materials·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 17, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Engineered Injectable Coaxial Supramolecular Hydrogel for a Minimally Invasive Neural Electrode.

Yuqi Tao¹, Fan Zhang², Daoyang Zhu¹

¹MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China.

ACS Applied Bio Materials

|June 16, 2026

Summary

This summary is machine-generated.

Injectable hydrogel electrodes overcome brain-computer interface challenges. These soft, self-healing electrodes mimic brain tissue mechanics, enabling stable, long-term neural signal recording and reducing inflammation.

Keywords:

conductivity flexible neural electrodes injectable hydrogels neural interfaces supramolecular interaction

More Related Videos

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Related Experiment Videos

Last Updated: Jun 17, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Insertion of Flexible Neural Probes Using Rigid Stiffeners Attached with Biodissolvable Adhesive

Published on: September 27, 2013

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Microinjectrode System for Combined Drug Infusion and Electrophysiology

Published on: November 13, 2019

Area of Science:

Biomaterials Science
Neuroengineering
Materials Chemistry

Background:

Long-term stability of implantable neural electrodes is crucial for brain-computer interfaces (BCIs).
Mechanical mismatch between rigid electrodes and soft neural tissue causes inflammation and signal degradation.
Existing electrode technologies face challenges in achieving biocompatibility and sustained performance.

Purpose of the Study:

To develop an injectable, mechanically compliant, and electrically robust neural electrode.
To address the limitations of rigid electrodes in neural interfacing.
To create a next-generation soft neural interface for stable neural recording.

Main Methods:

Fabrication of an injectable coaxial supramolecular hydrogel electrode using host-guest interactions (β-cyclodextrin and adamantane).
Incorporation of silver nanowires for enhanced electrical conductivity.
Characterization of hydrogel properties including shear-thinning, self-recovery, and mechanical matching to brain tissue.
In vivo implantation in a rat model for assessing performance over 14 days.

Main Results:

The hydrogel exhibited shear-thinning and rapid self-recovery, allowing minimally invasive injection and in situ electrode formation.
Tunable supramolecular crosslinking achieved tissue-matched mechanical properties, mitigating electrode-tissue mismatch.
Silver nanowire incorporation resulted in low impedance and stable electrochemical performance.
In vivo tests showed stable impedance and reliable neural signal recording for 14 days, capturing evoked responses and epileptic activity.

Conclusions:

Developed injectable, mechanically compliant, and electrically robust hydrogel neural electrodes.
Demonstrated the potential of supramolecular chemistry for creating advanced neural interfaces.
This approach offers a versatile strategy for next-generation soft neural interfaces with improved long-term stability and performance.