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Updated: Jul 11, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

Therapeutic Phage Monitoring: A Review.

Kiran Bosco^1,2, Stephanie Lynch^1,2, Indy Sandaradura^1,2,3,4

¹Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|November 6, 2023

Summary

This summary is machine-generated.

Therapeutic phage monitoring (TPM) is crucial for optimizing phage therapy (PT) by tracking phage levels and immune responses. This approach enhances understanding of phage-bacteria interactions and improves patient care in the face of antimicrobial resistance.

Keywords:

bacteria bacteriophage infectious disease‌phage therapy therapeutic phage monitoring

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Area of Science:

Microbiology
Immunology
Pharmacology

Background:

Growing antimicrobial resistance necessitates novel treatment strategies.
Phage therapy (PT) shows promise for treating bacterial infections.
Knowledge gaps exist regarding PT's in vivo efficacy and host response.

Approach:

Propose Therapeutic Phage Monitoring (TPM) as a key component of PT protocols.
Monitor phage concentrations in blood and tissues.
Track patient immune responses and ecological changes during PT.

Key Points:

TPM enables optimization of phage dosing and precision medicine.
It validates diagnostic surrogates and establishes quality assurance for phage products.
TPM enhances understanding of phage-bacteria-host interactions.

Conclusions:

TPM is essential for advancing phage therapy research and application.
Implementing TPM can lead to improved patient outcomes.
This monitoring strategy supports the development of best practices in PT.