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Phytochemical study on ethyl acetate fraction of Lepidium obtusum Basin
Gulnigar Ablikim1, Jun Li2, Haiqing Zhao2
1State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resources Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing South Road 40-1, Urumqi 830011, Xinjiang, China; University of Chinese Academy of Sciences, Beijing 100039, China.
Abstract:
Three undescribed compounds (1-3), including two butenolides and one indol alkaloids. Together with twenty-one known compounds (4-24) were isolated and identified from Lepidium obtusum Basin. Their structures were elucidated by spectroscopic analysis and ECD calculations. The isolated compounds were tested for their antimicrobial, antioxidant, and anti-inflammatory activities. Among them, compounds 11, 12, 14, 21 and 23 showed moderated antimicrobial activities against (Candida albicans, E. coli, Staphylococcus aureus). Compounds 11, 12, 14, 15, 17 and 18 exhibited potent antioxidant activities against ABTS and DPPH. Compound 1 exhibited moderated anti-inflammatory activities. Compounds 4-24 were isolated from this plant for the first time.
