Related Experiment Video
Updated: Jul 11, 2025
A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
Comparison of Cell-based and Nanoparticle-based Therapeutics in Treating Atherosclerosis
Wen Xi Goh1, Yih Yih Kok1, Chiew Yen Wong1
1Division of Applied Biomedical Science and Biotechnology, School of Health Sciences, International Medical University, Kuala Lumpur, Malaysia.
Insights
Cardiovascular diseases like atherosclerosis pose global health risks. New cell-based and nanoparticle therapies offer promising alternatives to current treatments for atherosclerosis, addressing limitations in efficacy and safety.
Area of Science:
- Cardiovascular Medicine
- Inflammatory Diseases
- Biomedical Engineering
Background:
- Cardiovascular diseases (CVDs) are a leading global public health concern.
- Atherosclerosis, a chronic inflammatory condition, underlies major CVDs like ischemic heart disease and stroke.
- Current atherosclerosis treatments lack optimal efficacy, safety, and patient acceptance.
Purpose of the Study:
- To review emerging cell-based and nanoparticle-based therapies for atherosclerosis.
- To analyze the principles, strengths, and weaknesses of these novel therapeutic approaches.
- To discuss targeted pathways, current trends, and recent mechanisms in combating atherosclerosis progression.
Main Methods:
- Review of current scientific literature on cell-based therapies for atherosclerosis.
- Analysis of research on nanoparticle-based drug delivery systems for atherosclerosis.
- Examination of targeted molecular pathways and recent advancements in atherosclerosis treatment.
Main Results:
- Cell-based therapies offer regenerative potential and targeted delivery for atherosclerosis.
- Nanoparticle-based therapies provide enhanced drug bioavailability and reduced systemic toxicity.
- Both approaches target key inflammatory and cellular processes implicated in atherosclerosis progression.
Conclusions:
- Cell-based and nanoparticle therapies represent promising frontiers in managing atherosclerosis.
- These advanced treatments aim to overcome the limitations of conventional atherosclerosis therapeutics.
- Further research is crucial to optimize these novel strategies for clinical application in atherosclerosis.
Abstract:
Today, cardiovascular diseases are among the biggest public health threats worldwide. Atherosclerosis, a chronic inflammatory disease with complex aetiology and pathogenesis, predispose many of these conditions, including the high mortality rate-causing ischaemic heart disease and stroke. Nevertheless, despite the alarming prevalence and absolute death rate, established treatments for atherosclerosis are unsatisfactory in terms of efficacy, safety, and patient acceptance. The rapid advancement of technologies in healthcare research has paved new treatment approaches, namely cell-based and nanoparticle-based therapies, to overcome the limitations of conventional therapeutics. This paper examines the different facets of each approach, discusses their principles, strengths, and weaknesses, analyses the main targeted pathways and their contradictions, provides insights on current trends as well as highlights any unique mechanisms taken in recent years to combat the progression of atherosclerosis.
