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Next-generation CTLA-4 targeting molecules and combination therapy: promising strategies for improving cancer
Nils-Petter Rudqvist1, Manushak Avagyan1, Dhan Chand1
1Agenus Inc, Lexington, MA, USA.
Abstract:
Radiation therapy and anti-CTLA-4 combination therapy can induce meaningful responses in some patients. Adding CD40 may provide additional benefit. Next-generation anti-CTLA-4 antibodies, such as botensilimab, are showing promise in clinical trials. Combining botensilimab with RT and/or CD40 agonist may offer additional benefits for challenging tumor types.
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