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Updated: Jul 11, 2025

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
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The Thyroid-cardiac Axis: Thyroid Function, Cardiac Rhythmology, and Sudden Cardiac Death

Michael Spartalis1, Eleftherios Spartalis2, Stavroula A Paschou3

  • 13rd Department of Cardiology, Sotiria Thoracic Diseases General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Endocrine, Metabolic & Immune Disorders Drug Targets
|November 8, 2023
PubMed

Insights

Thyroid dysfunction significantly elevates cardiovascular risks. Understanding the intricate links between thyroid hormones and heart health is crucial for personalized patient care and preventing cardiac events.

Area of Science:

  • Cardiology
  • Endocrinology
  • Thyroidology

Background:

  • Thyroid dysfunction is a known risk factor for cardiovascular mortality and morbidity.
  • Thyroid hormones exert pleiotropic effects on the cardiovascular system, impacting cardiac rhythm.
  • Existing research links thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels to cardiovascular events.

Approach:

  • System-based examination of thyroid homeostasis and cardiovascular disease.
  • Investigating the pathophysiological mechanisms underlying thyroid-cardiovascular associations.
  • Exploring novel study areas for managing cardiovascular risk.

Key Points:

  • Thyroid hormones influence normal cardiac rhythm and rhythm disturbances.
  • Correlations exist between TSH/FT4 levels and significant cardiovascular events.
  • Pathophysiological mechanisms require further elucidation.

Conclusions:

  • Inadequate definition of pathophysiological links between thyroid function and cardiovascular disease.
  • A system-based approach may reveal new research avenues.
  • Individualized strategies for managing cardiovascular risk can be developed.

Keywords:
Thyroidarrhythmiacardiovascular.hyperthyroidismhypothyroidismsudden cardiac death

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