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Association between omentin-1 and heart failure with preserved ejection fraction in Chinese elderly patients

Zhengjia Su1, Shuya Tian2, Wei Liang1

  • 1Department of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Clinical Cardiology
|November 8, 2023
PubMed

Insights

Omentin-1 levels are decreased in elderly heart failure with preserved ejection fraction (HFpEF) patients and correlate with inflammation. Lower omentin-1 is a protective factor for HFpEF, suggesting its diagnostic value.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biomarker Research

Background:

  • Omentin-1, a novel adipokine, is linked to chronic inflammation and cardiovascular diseases.
  • Its role in heart failure with preserved ejection fraction (HFpEF) among elderly populations remains unclear.
  • This study investigates omentin-1's association with HFpEF in Chinese elderly patients.

Purpose of the Study:

  • To determine if omentin-1 levels differ between elderly HFpEF patients and controls.
  • To explore the correlation between omentin-1 and HFpEF.
  • To assess omentin-1's diagnostic significance for HFpEF.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma omentin-1, TNF-α, and IL-6 levels.
  • 217 subjects (115 HFpEF patients, 102 controls) were analyzed.
  • Receiver operating characteristic (ROC) curve analysis evaluated omentin-1's diagnostic performance.

Main Results:

  • Omentin-1 levels were significantly lower in HFpEF patients compared to controls (14.02 vs. 19.74 ng/mL).
  • HFpEF patients showed elevated NT-proBNP, IL-6, and TNF-α levels.
  • Omentin-1 was a negative correlate of E/e' and NT-proBNP, and an independent protective factor for HFpEF (OR=0.948).
  • ROC analysis indicated omentin-1's diagnostic AUC was comparable to NT-proBNP (0.734 vs. 0.800).
  • In patients aged 70-80, omentin-1 demonstrated stronger predictive capability than NT-proBNP.

Conclusions:

  • Decreased omentin-1 levels in HFpEF patients are associated with inflammation.
  • Omentin-1 may serve as a valuable biomarker for the occurrence and progression of HFpEF in the elderly.
  • Further research could elucidate omentin-1's precise role in HFpEF pathophysiology.
Abstract

Keywords:
HFpEFelderly patientsomentin-1

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