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Ketamine for Traumatic Assault-Induced Depression: A Case Report.

Caitlyn B Coffelt¹, Kyle Gibson, Jason VanLandingham

¹University of Georgia College of Pharmacy, Athens, Georgia (Dr Coffelt); and Northeast Georgia Medical Center, Gainesville, Georgia (Ms Gibson and Dr VanLandingham).

Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses

|November 8, 2023

Summary

This summary is machine-generated.

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Ketamine offers rapid relief for depression following trauma. A single intravenous dose significantly improved mood and achieved remission in a patient experiencing severe depression after assault.

Area of Science:

Psychiatry
Pharmacology
Trauma Medicine

Background:

Trauma exposure increases risk for depression and PTSD.
Ketamine is an emerging alternative treatment for depression.

Observation:

A 68-year-old female developed severe depression post-assault and surgery.
Initial depression severity indicated by Montgomery-Asberg Depression Rating Scale (MADRS) score of 37.

Findings:

A single intravenous ketamine dose (0.5 mg/kg) rapidly improved mood.
MADRS score decreased to 16 within 4 hours, indicating mild depression.
Depression symptoms remitted within 24 hours, with MADRS score of 4.

Implications:

Ketamine shows potential as a rapid-acting antidepressant for trauma patients.

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This case highlights ketamine's efficacy in acute depression management.

Further research into ketamine for trauma-related depression is warranted.