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Updated: Jul 11, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Calcium(II)-Mediated Three-Component Selenofunctionalization of Alkenes under Mild Conditions
Minyao Kuang1, Haoran Li1, Zhongyi Zeng1
1Key Laboratory of Molecular Target & Clinical Pharmacology and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China.
Abstract:
A mild and general protocol involving amnio- and oxyselenation of diverse alkenes for the efficient synthesis of organo-Se compounds is achieved via an environmentally benign calcium-catalyzed three-component reaction. This selenofunctionalization reaction exhibits excellent substrate/functional group tolerance and high levels of chemo- and regioselectivity. Its utility was exemplified in the late-stage functionalization and even aggregation-induced emission luminogen labeling of organo-Se compounds.
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