Prospects of charged cyclodextrins in biomedical applications

Cyclodextrins (CDs), recognized for their unique ability to form inclusion complexes, have seen broad utilization across various scientific fields. Recently, there has been a surge of interest in the use of charged cyclodextrins for biomedical applications, owing to their enhanced properties, such as superior solubility and improved molecular recognition compared to neutral CDs. Despite the growing literature, a comprehensive review of the biomedical utilisations of multi-charged cyclodextrins is scarce. This review provides a comprehensive exploration of the emerging prospects of charged cyclodextrin-based assemblies in the field of biomedical applications. Focusing on drug delivery systems, the review details how charged CDs enhance drug solubility and stability, reduce toxicity, and enable targeted and controlled drug release. Furthermore, the review highlights the role of charged CDs in gene therapy, notably their potential for DNA/RNA binding, cellular uptake, degradation protection, and targeted gene delivery. The promising potential of charged CDs in antibacterial and antiviral therapies, including photodynamic therapies, biofilm control, and viral replication inhibition, is discussed. Concluding with a future outlook, this review highlights the potential challenges and advancements that could propel charged CDs to the forefront of biomedicine.