Suspected Aspergillus nodule histologically consistent with pulmonary nodular lymphoid hyperplasia:a case report

Area of Science:

• Pulmonology
• Pathology
• Infectious Diseases

Background:

• Aspergillus nodules (AN) represent an uncommon manifestation of chronic pulmonary aspergillosis.
• Pulmonary nodular lymphoid hyperplasia (PNLH) is categorized as a reactive pulmonary lymphoproliferative disorder.

Observation:

• A 65-year-old male presented with a left upper lobe lung nodule.
• Histological examination revealed significant lymphoid follicular hyperplasia and hyaline necrosis.
• Grocott staining identified Aspergillus species within the necrotic tissue.

Findings:

• The patient was diagnosed with suspected AN, histologically consistent with PNLH.
• This case highlights a potential overlap between AN and PNLH.

Implications:

• The findings suggest that Aspergillus infection might play a role in the pathophysiology of some PNLH cases.
• This case broadens the understanding of differential diagnoses for pulmonary nodules.