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Master Transcription Regulators

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...

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Updated: Jul 11, 2025

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

Published on: May 17, 2016

MYC function and regulation in physiological perspective.

Rajiv Kumar Jha¹, Fedor Kouzine¹, David Levens¹

¹Gene Regulation Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute (NCI), Bethesda, MD, United States.

Frontiers in Cell and Developmental Biology

|November 9, 2023

Summary

This summary is machine-generated.

The MYC proto-oncogene amplifies transcription, regulating crucial cellular processes. Understanding its normal biology is key to distinguishing its physiological roles from its pathological involvement in diseases like cancer.

Keywords:

DNA-topology MYC MYC function MYC regulation MYC-inhibitors transcription transcription-amplifier

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Last Updated: Jul 11, 2025

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

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Published on: May 17, 2016

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism

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Isolation and Differentiation of Primary Myoblasts from Mouse Skeletal Muscle Explants

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Published on: October 15, 2019

Area of Science:

Molecular Biology
Cell Biology
Oncology

Background:

MYC is a proto-oncogene regulating cell cycle, proliferation, metabolism, differentiation, and apoptosis.
MYC interacts with cofactors and regulators to control gene expression.
MYC deregulation is linked to various diseases, notably cancer.

Purpose of the Study:

To review recent advances in MYC's biological mechanisms, functions, and regulation.
To highlight MYC's role as a global transcription amplifier.
To differentiate physiological MYC functions from pathological roles.

Main Methods:

Literature review of recent scientific publications on MYC.
Analysis of MYC's interactions with cellular components.
Synthesis of information on MYC regulation and function.

Main Results:

MYC acts as a universal transcription amplifier, impacting numerous cellular processes.
Tight regulation of MYC levels is essential for normal cellular function.
Dysregulation of MYC contributes significantly to oncogenesis.

Conclusions:

Comprehensive understanding of MYC's physiological roles is crucial.
MYC's function as a global transcription amplifier is a key aspect of its biology.
Further research into MYC regulation is vital for therapeutic strategies against MYC-driven diseases.