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Updated: Jul 11, 2025

Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
Published on: January 3, 2020
Transformation of pancreatic nonfunctioning neuroendocrine tumor into metastatic insulinoma: A rare case report
Venkata S Buddhavarapu1, Gagandeep Dhillon2, Harpreet Singh Grewal3
1Hospital Medicine, Banner Medical Group, Banner Health Mesa Arizona USA.
Abstract:
Pancreatic neuroendocrine tumors can be classified as functional or nonfunctional based on hormone secretion. Management of each entity is different, with nonfunctional tumors being treated with traditional chemotherapy while functional tumors respond well to antihormonal therapy and immunologic agents. The conversion of one nonfunctional tumor into a functional tumor is an exceedingly rare event that complicates the overall management of these patients. In this report, we present the case of a 73-year-old woman who developed the conversion from a nonfunctional into a functional tumor and discuss the management options considered.

