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Advanced Sinonasal Malignant Melanoma; A Case Report.
Parisa Khorasani Esmaili1, Shahriar Dabiri1, Ayeh Shamsaddini2
1Department of Pathology, Pathology and Stem Cells Research Center, Afzali Pour Medical Faculty, Kerman University of Medical Sciences, Kerman, Iran.
Iranian Journal of Pathology
|November 9, 2023
Summary
Malignant melanoma of the sinonasal area is a rare, aggressive cancer. Early diagnosis and awareness of this mucosal melanoma are crucial for patient outcomes.
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Malignant melanoma of the sinonasal area is a rare neoplasm originating from mucosal melanocytes.
- It exhibits greater aggressiveness and a poorer prognosis compared to cutaneous melanoma.
Observation:
- A 60-year-old female presented with nasal cavity fullness, persistent epistaxis, and nasal bone deformity over two months.
- Physical examination revealed a black mass within the nasal cavity.
Findings:
- Excisional biopsy and subsequent immunohistochemical (IHC) staining confirmed the diagnosis of sinonasal malignant melanoma.
- The tumor was identified as a spindle cell neoplasm.
Implications:
- Sinonasal malignant melanoma should be considered in the differential diagnosis of spindle cell tumors in the head and neck region.
- Increased awareness may improve early detection and management of this rare malignancy.
