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Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Updated: Jul 12, 2026

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

[Bioprinting technologies in ophthalmology].

S V Kravchenko^1,2, S N Sakhnov^1,3, V V Myasnikova^1,3

¹Krasnodar branch of S.N. Fedorov National Medical Research Center "MNTK "Eye Microsurgery", Krasnodar, Russia.

Vestnik Oftalmologii

|November 9, 2023

Summary

Bioprinting technologies like extrusion are revolutionizing ophthalmology by enabling the creation of bioengineered eye tissues and models. This advanced fabrication method holds promise for regenerative medicine and developing new treatments for vision disorders.

Keywords:

3D-bioprinting biofabrication bioprinter bioprinting neuroprosthesis organ-on-a-chip tissue engineering

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Last Updated: Jul 12, 2026

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

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Published on: April 21, 2016

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Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Bioprinting of Cartilage and Skin Tissue Analogs Utilizing a Novel Passive Mixing Unit Technique for Bioink Precellularization

Published on: January 3, 2018

Area of Science:

Biotechnology
Regenerative Medicine
Ophthalmology

Background:

Bioprinting enables the additive fabrication of bioengineered constructs with precise cellular organization.
This technology utilizes live cells, biopolymers, and various materials for creating complex biological structures.

Conclusions:

Bioprinting technologies are crucial for advancing regenerative medicine in ophthalmology, particularly for cornea and retinal tissue engineering.
The fabrication of ocular tissue equivalents and microphysiological systems offers new avenues for fundamental research and preclinical studies.
Bioprinting also presents a promising approach for developing biocompatible electrode arrays for visual neuroprostheses.