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[Guillain-Barre syndrome in children]

A A Kozyreva1,2, R Ts Bembeeva1,2, E S Druzhinina1,2

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|November 9, 2023
PubMed

Insights

Guillain-Barré syndrome (GBS) is an immune disorder affecting the nervous system, causing progressive muscle weakness. Early diagnosis and treatment are crucial, especially in children, due to potential life-threatening complications.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Guillain-Barré syndrome (GBS) is an immune-mediated peripheral nervous system disorder.
  • It presents as progressive, symmetrical, ascending muscle weakness in children and adults.
  • Life-threatening complications include respiratory failure and autonomic dysfunction, necessitating vigilant monitoring.

Approach:

  • This review analyzes current medical literature on pediatric GBS.
  • It discusses diagnostic strategies and management tactics for GBS.
  • The review incorporates Russian and European clinical recommendations for GBS patient care.

Key Points:

  • GBS diagnosis can be challenging due to its expanding spectrum and atypical presentations.
  • Timely pathogenetic therapy is vital for favorable outcomes, particularly in pediatric cases.
  • Meticulous patient monitoring is essential to manage potential severe complications.

Conclusions:

  • Effective management of pediatric Guillain-Barré syndrome requires early recognition and prompt, guideline-adherent treatment.
  • Understanding the evolving diagnostic criteria and management protocols is key for clinicians.
  • This review synthesizes current knowledge to aid in diagnosing and treating GBS in children.

Keywords:
flaccid paralysispediatric Guillain—Barre syndromepediatric acute inflammatory demyelinating polyneuropathypolyradiculoneuropathy

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