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Updated: Jul 11, 2025

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Published on: November 9, 2019
Stereoselective Construction of β-chiral Homoallyl Functionalities by Substrate- and Reagent-Controlled Iterative
Elvira Linne1, Markus Kalesse1,2
1Institute of Organic Chemistry (OCI), Gottfried Wilhelm Leibniz Universität Hannover, 30167 Hannover, Germany.
Abstract:
Homoallylic alcohols possessing chiral β-centers are considered highly valuable in the synthesis of polyketide-based natural products. Therefore, there is a significant demand for new methods that allow for their stereoselective access. In pursuit of this objective, we have successfully combined our substrate-controlled protocol of Hoppe-Matteson-Aggarwal chemistry with iterative 1,2-metallate rearrangements. Notably, this approach has proven effective in introducing not only primary alcohols but also other functional groups such as alkynes and protected amines.
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