A comparison of cumulated CK release with three vectorcardiographic methods of estimating myocardial infarct size

Infarct size estimated by three vectoracardiographic methods was compared with cumulated CK release in 66 patients admitted to hospital within five hours after onset of myocardial infarction. Infarctional changes in the QRS complex were sequentially computed from a continuous 24-hour recording of Frank lead VCG by: (I)-the integrals of QRS vector differences (QRS-VD) relative to the first recording obtained after hospitalization, (II)-the integral of spatial magnitude during the period of initial abnormal depolarization (IAD), (III)-The sum of R-wave amplitude in leads X and Y and Q-wave amplitude in lead Z (sigma R). From the time-trend curves of cumulated CK release, QRS-VD, IAD and sigma R terminal plateau levels were visually determined representing estimated infarct size (ISCK, ISQRS-VD, ISIAD and IS sigma R). The correlation coefficients were: between ISCK and ISQRS-VD r = 0.62, p less than 0.001, ISCK and ISIAD r = 0.22, p = NS, ISCK and IS sigma R r = -0.22, p = NS. The correlation for ISQRS-VD was significantly better than for ISIAD (p = 0.011) and IS sigma R (p = 0.005). The IAD time-trend curves were inconsistent, falling in 24 and rising in 24 patients. For sigma R the corresponding figures were 56 and 10 patients. Thus, neither IAD nor sigma R have been shown to predict infarct size correctly at an early stage or to describe infarct evolution adequately.(ABSTRACT TRUNCATED AT 250 WORDS)