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Benzyl violet 4B (BV-4B), a surgical suture component, enables real-time, noninvasive monitoring of implanted medical devices. This fluorescence imaging in the second near-infrared window (NIR-II) tracks device degradation and integrity in vivo.

Keywords:
NIR-II fluorescenceaggregatesin vivo imagingmedical devices

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Medical Imaging

Background:

  • Monitoring implanted medical devices noninvasively in real-time remains a significant clinical challenge.
  • Current methods lack the ability to track device migration, integrity, and biodegradation effectively within the human body.

Purpose of the Study:

  • To investigate benzyl violet 4B (BV-4B) as a fluorescent agent for in vivo monitoring of medical devices.
  • To explore the potential of BV-4B for near-infrared window (NIR-II) fluorescence imaging of implanted materials.

Main Methods:

  • Characterization of BV-4B fluorescence properties in polar solutions and self-assembled nanodots.
  • In vivo monitoring of BV-4B-labeled surgical sutures and coated silicone catheters using NIR-II imaging.
  • Application of BV-4B in hybrid fluorescence-guided surgery (FGS) for arteriovenous malformation embolization.
  • Clinical proof-of-concept imaging of surgical sutures during patient operations.

Main Results:

  • BV-4B exhibits fluorescence in the first near-infrared window (NIR-I) in solution and strong NIR-II fluorescence upon self-assembly into nanodots.
  • Facile in vivo monitoring of suture degradation and noninvasive diagnosis of catheter rupture were achieved using BV-4B and NIR-II imaging.
  • Hybrid FGS using BV-4B-loaded embolization glue was successfully demonstrated.
  • Solid-state BV-4B enabled NIR-II imaging of surgical sutures in clinical operations.

Conclusions:

  • BV-4B is a clinically translatable solid-state dye with dual NIR-I/NIR-II fluorescence properties.
  • BV-4B enables noninvasive, real-time in vivo monitoring of medical device fate via NIR-II imaging.
  • This technology holds promise for improved surgical guidance and post-operative device assessment.