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Clinically Translatable Solid-State Dye for NIR-II Imaging of Medical Devices
Deling Li1,2, Hui Shi2,3,4,5, Qingrong Qi2,6
1Department of Neurosurgery, Beijing Tiantan Hospital, China National Clinical Research Center for Neurological Diseases, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 10, 2023
Summary
Benzyl violet 4B (BV-4B), a surgical suture component, enables real-time, noninvasive monitoring of implanted medical devices. This fluorescence imaging in the second near-infrared window (NIR-II) tracks device degradation and integrity in vivo.
Area of Science:
- Biomedical Engineering
- Materials Science
- Medical Imaging
Background:
- Monitoring implanted medical devices noninvasively in real-time remains a significant clinical challenge.
- Current methods lack the ability to track device migration, integrity, and biodegradation effectively within the human body.
Purpose of the Study:
- To investigate benzyl violet 4B (BV-4B) as a fluorescent agent for in vivo monitoring of medical devices.
- To explore the potential of BV-4B for near-infrared window (NIR-II) fluorescence imaging of implanted materials.
Main Methods:
- Characterization of BV-4B fluorescence properties in polar solutions and self-assembled nanodots.
- In vivo monitoring of BV-4B-labeled surgical sutures and coated silicone catheters using NIR-II imaging.
- Application of BV-4B in hybrid fluorescence-guided surgery (FGS) for arteriovenous malformation embolization.
- Clinical proof-of-concept imaging of surgical sutures during patient operations.
Main Results:
- BV-4B exhibits fluorescence in the first near-infrared window (NIR-I) in solution and strong NIR-II fluorescence upon self-assembly into nanodots.
- Facile in vivo monitoring of suture degradation and noninvasive diagnosis of catheter rupture were achieved using BV-4B and NIR-II imaging.
- Hybrid FGS using BV-4B-loaded embolization glue was successfully demonstrated.
- Solid-state BV-4B enabled NIR-II imaging of surgical sutures in clinical operations.
Conclusions:
- BV-4B is a clinically translatable solid-state dye with dual NIR-I/NIR-II fluorescence properties.
- BV-4B enables noninvasive, real-time in vivo monitoring of medical device fate via NIR-II imaging.
- This technology holds promise for improved surgical guidance and post-operative device assessment.
