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Related Experiment Video

Updated: Jul 11, 2025

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Biocompatible Ferrofluid-Based Millirobot for Tumor Photothermal Therapy in Near-Infrared-II Window.

Yiming Ji1, Xue Bai2, Hongyan Sun1

  • 1School of Mechanical Engineering & Automation, Beihang University, Beijing, 100191, China.

Advanced Healthcare Materials
|November 10, 2023
PubMed
Summary

This study introduces a biocompatible ferrofluid millirobot for in vivo tumor therapy. The robot uses magnetic control and photothermal properties to effectively target and destroy cancer cells within the body.

Keywords:
biocompatibilityferrofluid robotstargeted therapy

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Ferrofluidic robots show promise for medical applications but face challenges in in vivo use.
  • Existing research primarily focuses on in vitro studies, limiting clinical translation.

Purpose of the Study:

  • To develop a ferrofluid-based millirobot for in vivo tumor-targeted therapy.
  • To address biocompatibility, controllability, and therapeutic efficacy for in vivo applications.

Main Methods:

  • Utilized corn oil for biocompatibility in the ferrofluid robot.
  • Developed a 3D magnetic drive control system for navigation in complex biological media.
  • Leveraged 1064 nm photothermal conversion for tumor cell destruction.

Main Results:

  • Demonstrated in vitro tumor cell killing.
  • Inhibited tumor volume growth and destroyed tumor interstitium in vivo.
  • Increased tumor cell apoptosis and inhibited proliferation in vivo.

Conclusions:

  • The ferrofluid millirobot shows potential for in vivo tumor-targeted therapy.
  • This research provides a foundation for developing ferrofluid-based millirobots for clinical applications.