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Advances, opportunities and challenges in developing therapeutic cancer vaccines

Zhihui Duan1, Dandan Yang1, Ping Yuan1

  • 1Laboratory of Structural Immunology, Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

Critical Reviews in Oncology/Hematology
|November 10, 2023
PubMed

Insights

Therapeutic cancer vaccines show promise in immunotherapy, but systematic characterization is needed. This review details vaccine types, efficacy, safety, and combination strategies for future development.

Area of Science:

  • Immunology
  • Oncology
  • Vaccinology

Background:

  • Therapeutic cancer vaccines show promise for immunotherapy.
  • Systematic characterization of their clinical application and efficacy improvement is lacking.

Purpose of the Study:

  • To systematically review therapeutic cancer vaccines.
  • To summarize their classification, clinical efficacy, safety, and combination strategies.

Main Methods:

  • Literature review and synthesis.
  • Classification of vaccines by type and delivery form.
  • Outline of clinical data and combination strategies.

Main Results:

  • Categorized therapeutic cancer vaccines into protein, nucleic acid, cellular, and anti-idiotypic antibody types.
  • Detailed vaccine subtypes and delivery forms.
  • Summarized clinical efficacy, safety profiles, and combination therapies.

Conclusions:

  • Therapeutic cancer vaccines are a developing field with diverse approaches.
  • Understanding their efficacy, safety, and combinations is crucial for future clinical applications.
  • This review provides a rationale for advancing therapeutic cancer vaccine development.
Keywords:
Combination therapyTherapeutic cancer vaccineTumor antigen

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