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Nonhyperemic Pressure Ratios-All the Same or Nuanced Differences?
Samineh Sehatbakhsh1, Weijia Li2, Tatsunori Takahashi2
1Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 210th Street, Bronx, NY 10467, USA.
Cardiology Clinics
|November 10, 2023
Summary
Fractional flow reserve (FFR) is the standard for assessing coronary artery disease (CAD). This review explores wire-based alternatives to FFR, addressing limitations in daily practice.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Devices
Background:
- Fractional flow reserve (FFR) is the gold standard for assessing the functional significance of coronary artery disease (CAD).
- Evidence supporting FFR in the cardiac catheterization laboratory is extensive.
- Limited daily practice uptake of FFR is due to invasive procedures and need for hyperemia-inducing medications.
Purpose of the Study:
- To review wire-based alternatives to FFR.
- To provide insights into the development of these alternatives.
- To discuss the clinical evidence and limitations of FFR alternatives.
Main Methods:
- Literature review of wire-based FFR alternatives.
- Analysis of development pathways for these technologies.
- Evaluation of existing clinical data and identified limitations.
Main Results:
- Several wire-based alternatives to FFR have been developed.
- These alternatives aim to overcome FFR's practical limitations.
- Clinical evidence and specific limitations for each alternative are detailed.
Conclusions:
- Wire-based alternatives offer potential solutions to FFR's limitations in clinical practice.
- Further research and validation are ongoing for these emerging technologies.
- Understanding their development, evidence, and limitations is crucial for guiding future adoption.
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