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Updated: Jul 11, 2025

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
Published on: November 11, 2016
Generation and characterization of induced pluripotent stem cells from breast cancer patients carrying ATM mutations
Mao Zhang1, Ravichandra Venkateshappa1, Audrey Li2
1Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Abstract:
We generated two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells (PBMCs) of breast cancer patients carrying germline ATM mutations, a gene associated with a 7% prevalence in breast cancer. These iPSC lines displayed typical morphology, expressed pluripotency markers, maintained a stable karyotype, and retained the ability to differentiate into the three germ layers. These patient-specific iPSC lines hold great potential for mechanistic investigations and the development of drug screening strategies aimed at addressing ATM-related cancer.
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