Related Experiment Video
Updated: Aug 6, 2026

10:08
Pseudofracture: An Acute Peripheral Tissue Trauma Model
Published on: April 18, 2011
Trauma as a life-lengthening agency--a biologic paradox
The Journal of Trauma
|December 1, 1986
Summary
Chest compression after myocardial infarction rupture created fistulae, relieving cardiac tamponade. This allowed the heart to continue beating when it otherwise would have stopped.
Area of Science:
- Cardiology
- Trauma Medicine
- Medical Physiology
Background:
- Spontaneous rupture of the free wall in acute myocardial infarction can lead to fatal pericardial tamponade.
- Pericardial tamponade restricts cardiac filling and output, often resulting in cessation of cardiac contractions.
- Prompt intervention is critical for survival in cases of myocardial rupture and tamponade.
Observation:
- Traumatic antero-posterior chest compression was applied immediately following spontaneous myocardial infarction rupture.
- The chest compression created pericardio-pleural fistulae.
- These fistulae resulted in the relief of pericardial tamponade.
Findings:
- The created pericardio-pleural fistulae effectively drained pericardial fluid, alleviating pressure on the heart.
- Relief of pericardial tamponade permitted the resumption and continuation of cardiac contractions.
- The intervention enabled cardiac function despite the myocardial rupture.
Implications:
- This case suggests a potential, albeit unconventional, method for managing pericardial tamponade secondary to myocardial rupture.
- The findings highlight the critical role of pressure dynamics in the pericardial space for cardiac function.
- Further investigation into the therapeutic potential and risks of induced pericardio-pleural fistulae in specific cardiac emergencies may be warranted.
Related Concept Videos
Overview of Regeneration and Repair
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Regeneration
All animals have varying degrees of...
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Chronic Inflammation: Introduction
Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Traumatic Brain Injury l: Introduction
DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...
Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...

