Ensembl 2024

Area of Science:

• Genomics
• Bioinformatics
• Comparative Genomics

Background:

• Ensembl has been a key genomic resource for over 20 years, providing annotations and tools for vertebrates and model organisms.
• The genomic landscape is rapidly evolving with an increase in high-quality reference genomes and pan-genome representations.
• There is a growing need for scalable annotation and analysis tools to support biodiversity and agricultural research.

Purpose of the Study:

• To scale Ensembl's capacity for rapid annotation of new genome assemblies.
• To develop advanced methods for comparative genomic analysis.
• To enhance the depth and quality of genome annotations and support global research efforts.

Main Methods:

• Continued expansion of annotated genomes on the Ensembl Rapid Release site, doubling the number to over 1700.
• Strengthened support for agricultural species, including regulatory builds for farmed animals.
• Updates to key tools such as the Ensembl Variant Effect Predictor.

Main Results:

• Over 1700 annotated genomes now available on the Rapid Release site, supporting global biodiversity research.
• Enhanced regulatory annotation for key agricultural species.
• Improved tools and resources available to the scientific community.

Conclusions:

• Ensembl continues to adapt to the evolving genomic landscape by scaling its annotation capabilities and expanding its resource breadth.
• The platform's focus on comparative analysis and annotation quality supports global biodiversity and agricultural research.
• Freely available Ensembl data, software, and tools accelerate downstream scientific discovery.