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Related Experiment Video

Updated: Jul 11, 2025

Finite Element Modelling of a Cellular Electric Microenvironment

Finite Element Modelling of a Cellular Electric Microenvironment

Published on: May 18, 2021

Electric field bridging-effect in electrified microfibrils' scaffolds.

Sara Fontana^1,2, Laura Caramazza^1,2, Paolo Marracino³

¹BioEM Lab, Department of Information Engineering, Electronics and Telecommunications (DIET), Sapienza University of Rome, Rome, Italy.

Frontiers in Bioengineering and Biotechnology

|November 13, 2023

Summary

Aligned Polylactic Acid (PLA) microfibril scaffolds enhance electrical field distribution for neural stem cell therapy. This study shows PLA scaffolds effectively focus electric fields, promoting cell exposure for spinal cord injury regeneration.

Keywords:

biocompatible scaffold dosimetry electric stimulation microfibrils numerical modeling tissue engineering

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Electric and Magnetic Field Devices for Stimulation of Biological Tissues

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Published on: May 15, 2021

Area of Science:

Biomaterials Science
Neuroscience
Electrical Engineering

Background:

Biocompatible scaffolds with neural stem cells are crucial for neural tissue regeneration, especially after spinal cord injury (SCI).
Aligned Polylactic Acid (PLA) microfibril scaffolds support cell survival and neural differentiation.
PLA's insulating nature poses challenges for electrical functionalization of scaffolds.

Purpose of the Study:

To investigate the effect of PLA microfibril scaffolds on electric field (E-field) distribution in planar interdigitated electrodes.
To assess the suitability of PLA scaffolds for electrical stimulation in neural regeneration applications.

Main Methods:

Numerical study using Comsol Multiphysics software.
Creation of realistic 3D CAD models of microfibril scaffolds.
Numerical dosimetry to analyze E-field distribution under applied voltage.

Main Results:

PLA microfibrils effectively redistribute and focus E-field streamlines in the spaces between fibers.
Maximum E-field values reached up to 100 kV/m, comparable to devices without scaffolds.
The median E-field within scaffolded electrodes was 90% of the nominal field, ensuring adequate cell exposure.

Conclusions:

PLA microfibril scaffolds facilitate effective electrical field delivery for neural stem cell applications.
The findings support the integration of electrical stimulation with PLA scaffolds for enhanced neural tissue repair.
This research contributes to the development of functionalized scaffolds for regenerative medicine.