Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcatheter embolization of an endoleak through a vascular plug implanted in the left common iliac artery during aortouni-iliac endovascular aortic repair: A case report.

Radiology case reports·2026
Same author

Haplotype analysis of spinocerebellar ataxia type 36 suggests a shared permissive core haplotype across populations.

Journal of human genetics·2026
Same author

Two scripts, two pathways: dorsal-ventral biases in post-stroke kana-kanji agraphia.

Brain : a journal of neurology·2026
Same author

Endovascular stent-graft repair of anastomotic pseudoaneurysms after aortic arch replacement: A case series of 3 patients.

Radiology case reports·2026
Same author

Enhanced shielding effectiveness for scattered X-rays in diagnostic radiology using origami-inspired 3D tungsten functional paper structures.

European journal of radiology·2026
Same author

Robustness of heart dose against cardiac cycle in breast cancer radiotherapy with deep inspiration breath-hold.

Radiological physics and technology·2026

Related Experiment Video

Updated: Jul 11, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.8K

Comparing Dose Calculation Algorithms for Heterogeneous Media: Analytical Anisotropic Algorithm Versus Acuros XB

Yuya Yanagi1,2, Kazuki Kubo1, Takaaki Ito1

  • 1Department of Medical Physics, Graduate School of Medical Sciences, Kindai University, Osakasayama, JPN.

Cureus
|November 13, 2023
PubMed
Summary

This study compared dose calculations from analytical anisotropic algorithm (AAA) and Acuros XB (AXB) in heterogeneous materials. Significant dose differences were observed across a wide CT value range, highlighting potential clinical risks.

Keywords:
acuros xb (axb)analytical anisotropic algorithm (aaa)ct valueheterogeneous materialhounsfield unit (hu)

More Related Videos

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.3K
Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

11.9K

Related Experiment Videos

Last Updated: Jul 11, 2025

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation
10:33

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification ADCI and Dose Estimation

Published on: September 4, 2017

15.8K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.3K
Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

11.9K

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Dosimetry

Background:

  • Accurate dose calculation is critical in radiation therapy, especially in heterogeneous tissues.
  • The analytical anisotropic algorithm (AAA) and Acuros XB (AXB) are widely used dose calculation algorithms.
  • Variations in CT values significantly impact dose calculations in heterogeneous environments.

Purpose of the Study:

  • To compare dose calculations between AAA and two AXB dose reporting modes (AXB(Dm) and AXB(Dw)).
  • To evaluate these algorithms across a broad spectrum of CT values (-1000 to 3000 HU) in heterogeneous materials.
  • To assess the clinical implications of dose discrepancies in radiation therapy planning.

Main Methods:

  • Virtual phantoms with heterogeneous material layers (2 or 5 cm thickness) were created in Eclipse.
  • Simulations used single or opposed fields, 5x5 cm² or 10x10 cm² field sizes, and 6 or 10 MV photon energies.
  • Relative doses were calculated at the center of the heterogeneous layer and normalized to the dose at 0 HU.

Main Results:

  • Pronounced dose differences were observed between AAA and AXB algorithms, particularly for a 5 cm heterogeneous layer with a single 6 MV, 5x5 cm² field.
  • In low-density regions (-1000 to -800 HU), AXB showed dose differences of -54.5% (AXB(Dm)) and -47.0% (AXB(Dw)) relative to AAA.
  • In high-density regions (1000 to 3000 HU), dose differences ranged from -5.7% to -8.8% (AXB(Dm)) and +7.4% to +3.5% (AXB(Dw)).

Conclusions:

  • Significant dose differences exist between AAA and AXB algorithms in heterogeneous materials across a wide CT range.
  • These discrepancies highlight a clear risk of under- or over-dosing in clinical applications.
  • The study underscores the importance of algorithm selection and verification for patient safety in radiation therapy.