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Atomically precise photothermal nanomachines.

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Researchers created hybrid nanomachines by linking gold nanoclusters with molecular rotors. These nanomachines use near-infrared light for efficient photothermal ablation of tumors, showing promise for nanomachine-based theranostics.

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Interfacing molecular machines with inorganic nanoparticles can create hybrid nanomachines with enhanced functionalities.
  • Developing atomically precise hybrid nanomachines requires advanced interfacing strategies.

Purpose of the Study:

  • To engineer atomically precise hybrid nanomachines by interfacing gold nanoclusters with tetraphenylethylene molecular rotors.
  • To investigate the energy dissipation mechanisms and stability of these hybrid nanomachines under near-infrared (NIR) irradiation.
  • To evaluate the therapeutic potential of these nanomachines for cancer treatment.

Main Methods:

  • Ligand engineering approach for interfacing gold nanoclusters and tetraphenylethylene molecular rotors.
  • Near-infrared (NIR) light irradiation to activate photothermal properties.
  • Solid-state nuclear magnetic resonance (ssNMR) and femtosecond transient absorption spectroscopy to study electron dynamics.
  • In vitro and in vivo studies in mammalian cells and tumor-bearing mice.

Main Results:

  • Demonstrated the development of atomically precise hybrid nanomachines via gold nanocluster and tetraphenylethylene rotor interfacing.
  • Observed efficient energy dissipation through molecular rotor rotation upon NIR irradiation, maintaining nanomachine stability and efficiency.
  • Spectroscopic analysis revealed rapid cooling of photogenerated hot electrons via electron-phonon coupling within picoseconds.
  • Confirmed structural and functional integrity of the nanomachine in biological environments (cells and in vivo).

Conclusions:

  • The engineered hybrid nanomachines are stable and efficient for photothermal applications.
  • These nanomachines exhibit promising therapeutic efficacy, achieving complete tumor ablation without recurrence in mice following a single NIR irradiation dose.
  • The findings highlight the potential of nanomachine-based theranostics for cancer treatment.