Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 27, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Programmable Hierarchical Assembly of Atomically Precise Metal Nanoclusters Using Supra-Amphiphilic Nucleic Acids.

Gaoang Zhou1, Siyuan Zhang1,2, Yan Zhou1

  • 1State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

JACS Au
|June 26, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disruption of microtubules with low intensity ultrasound rescues hair follicle damage by paclitaxel in mouse models.

Nature communications·2026
Same author

Targeted Delivery of Indole-3-Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8<sup>+</sup> T Cell-Mediated Immunotherapy Response in Bladder Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Enhanced Anti-Counterfeiting Using Dynamic Encryption with Dual Physically Unclonable Functions.

ACS applied materials & interfaces·2026
Same author

Author Correction: Atomically precise photothermal nanomachines.

Nature materials·2026
Same author

Vancomycin combined with Zhenqi Granule can inhibit Methicillin-Resistant Staphylococcus aureus more effectively than Vancomycin alone.

Microbial pathogenesis·2026
Same author

DNA Framework Nucleator-Enabled Intelligent Hydrogel Interfaces on Living Cells.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same journal

DeepDOX1: A Dual-Drive Framework Integrating Deep Learning and First-Principles Quantum Chemistry for Drug-Protein Affinity Prediction.

JACS Au·2026
Same journal

Catalyst-Controlled Regiodivergent C-H Olefination of Furanyl Carbamates through a Rational Approach.

JACS Au·2026
Same journal

Charting the Biosynthetic Landscape of Hybrid Polyketide-Nonribosomal Peptide-Specialized Lipids.

JACS Au·2026
Same journal

Valence-State-Dependent Surface Lattice Oxygen in CeO<sub>2</sub>‑Modified VPO Catalysts: Elucidating the Mechanism of <i>n</i>‑Butane Selective Oxidation to Maleic Anhydride.

JACS Au·2026
Same journal

Quantitative Insights into Pressure-Dependent Mass Transport and Reaction Kinetics in Electrochemical CO<sub>2</sub> Reduction.

JACS Au·2026
Same journal

3‑Methylthiopropionic Acid Kills Carbapenem-Resistant <i>Klebsiella pneumoniae</i> by Disrupting Membrane Integrity and Bioenergetics.

JACS Au·2026
See all related articles
This summary is machine-generated.

Researchers developed a novel method for creating self-assembling, amphiphilic nucleic acids using gold nanoclusters. This breakthrough enables the construction of versatile functional nanomaterials for diverse applications.

Area of Science:

  • Nanotechnology
  • Supramolecular Chemistry
  • Materials Science

Background:

  • Amphiphilic nucleic acids are key for creating functional nanosystems.
  • Current methods rely on covalent conjugation, limiting design flexibility.
  • Noncovalent assembly of amphiphilic nucleic acid architectures is a significant challenge.

Purpose of the Study:

  • To develop a noncovalent strategy for assembling supra-amphiphilic nucleic acids.
  • To create tunable, self-assembling nanomaterials using gold nanoclusters and DNA.
  • To establish a versatile platform for advanced nanomaterial construction.

Main Methods:

  • Utilized partially phosphorothioate-modified single-stranded DNA and gold nanoclusters (Au NCs) as building blocks.
  • Assembly driven by hydrophobic interactions and coordination between DNA and Au NCs.
Keywords:
DNA origamihierarchical assemblymetal nanoclustersingle-stranded DNAsupra-amphiphiles

More Related Videos

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures
08:02

Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures

Published on: May 31, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures
08:02

Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures

Published on: May 31, 2024

  • Tuned micelle size by modulating the hydrophilic DNA segment length in the presence of Mg2+.

    • Main Results:

    • Successfully assembled supra-amphiphilic nucleic acids via noncovalent interactions.
    • Created well-defined micelles with tunable sizes through self-assembly.
    • Demonstrated programmable higher-order assembly via DNA hybridization and DNA origami scaffolds.

    Conclusions:

    • Established a versatile, noncovalent platform for constructing functional nanomaterials.
    • Enabled programmable supramolecular assembly of DNA-nanocluster hybrids.
    • Opened new avenues for applications in catalysis, bioimaging, and nanodevices.