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Related Concept Videos

Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
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Updated: Jun 13, 2026

Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics (DCAF)
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Enhanced Anti-Counterfeiting Using Dynamic Encryption with Dual Physically Unclonable Functions.

Yanan Wang1, Zhenfeng Zhang1, Xun Yang1

  • 1Henan Key Laboratory of Diamond Optoelectronic Material and Devices, Key Laboratory of Materials Physics, Ministry of Education, School of Physics and Laboratory of Zhongyuan Light, Zhengzhou University, Zhengzhou 450052, China.

ACS Applied Materials & Interfaces
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces an advanced optical Physical Unclonable Function (PUF) tag utilizing Raman spectroscopy for enhanced security. The novel dual-encryption strategy with dynamic key assignment offers robust anticounterfeiting and information protection.

Keywords:
Ramandynamic encryptionmicrowiresmultiple encryptionsphysical unclonable functions

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Area of Science:

  • Materials Science
  • Optoelectronics
  • Information Security

Background:

  • Physical unclonable functions (PUFs) are crucial for securing information by leveraging unique physical properties.
  • Existing PUF technologies face challenges in achieving high security and preventing counterfeiting.

Purpose of the Study:

  • To develop an advanced optical PUF tag with a multilayered encryption strategy.
  • To enhance information security and anticounterfeiting performance through novel techniques.

Main Methods:

  • Utilized Raman spectroscopy to detect multiple peaks from microwires (MWs) of various materials.
  • Implemented dual encryption using distinctive Raman peaks (Ga2O3 and ZnO) for key generation.
  • Employed Raman mapping for unique key generation and dynamic assignment (Key A/B).

Main Results:

  • Each PUF tag generated two unique keys based on Raman mapping.
  • High consistency was observed between keys from the same tag.
  • Significant differences were found between keys from different tags, confirming uniqueness.

Conclusions:

  • The developed optical PUF tag offers a robust dual-encryption strategy.
  • Dynamic key assignment further bolsters security levels against unauthorized access.
  • This approach significantly enhances information security and anticounterfeiting capabilities.