Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease01:22

Chronic Obstructive Pulmonary Disease

1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.8K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

953
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
953
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

274
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
274
Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycemic Variability and Continuous Glucose Monitoring in Occupational Health: A Narrative Review of Emerging Evidence and Potential Applications in Working Populations.

Healthcare (Basel, Switzerland)·2026
Same author

Current perspectives on β<sub>2</sub>-adrenergic receptor agonists in asthma: navigating from track to track within GINA recommendations.

Expert opinion on pharmacotherapy·2026
Same author

Real-World Effectiveness and Safety of Extrafine Triple Therapy in COPD Patients with Comorbid and Cardiovascular Conditions.

International journal of chronic obstructive pulmonary disease·2026
Same author

Remission in Global Airway Diseases: EUFOREA Consensus Paper.

Allergy·2026
Same author

The preclinical discovery and development of depemokimab for severe eosinophilic asthma.

Pulmonary pharmacology & therapeutics·2026
Same author

TQC3721: Expanding the Role of Dual Phosphodiesterase 3/4 Inhibition in COPD Management.

Chest·2026

Related Experiment Video

Updated: Jul 11, 2025

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.2K

Hyperglycaemia and Chronic Obstructive Pulmonary Disease.

Mario Cazzola1, Paola Rogliani1,2, Josuel Ora2

  • 1Unit of Respiratory Medicine, Department of Experimental Medicine, University of Rome 'Tor Vergata', 00133 Rome, Italy.

Diagnostics (Basel, Switzerland)
|November 14, 2023
PubMed
Summary

Type 2 diabetes mellitus (T2DM) and chronic obstructive pulmonary disease (COPD) often coexist, impacting treatment. Targeting shared inflammation offers a promising therapeutic strategy for managing both T2DM and COPD effectively.

Keywords:
chronic obstructive pulmonary diseasehyperglycaemialung functionpharmacological interferencessystemic inflammationtype 2 diabetes mellitus

More Related Videos

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD &#8212; A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

813
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

1.5K

Related Experiment Videos

Last Updated: Jul 11, 2025

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.2K
Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD &#8212; A Safe, Cost-Effective Approach
04:53

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD — A Safe, Cost-Effective Approach

Published on: October 18, 2024

813
Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique
07:35

Author Spotlight: Investigating the Blood Glucose Homeostasis in Murine Brain Using a Cost-Effective Hyperglycemic And Hypoglycemic Clamp Technique

Published on: January 26, 2024

1.5K

Area of Science:

  • Pulmonology
  • Endocrinology
  • Internal Medicine

Background:

  • Chronic obstructive pulmonary disease (COPD) and type 2 diabetes mellitus (T2DM) frequently coexist, presenting complex clinical challenges.
  • COPD patients exhibit an increased risk of developing T2DM, while hyperglycemia in diabetes is linked to reduced lung function.
  • The intricate mechanistic links between COPD and T2DM are not fully understood but significantly influence treatment decisions.

Purpose of the Study:

  • To explore the interconnectedness between COPD and T2DM.
  • To examine the potential risks and benefits of pulmonary drugs in T2DM patients and antidiabetic drugs in COPD patients.
  • To identify pharmacological strategies that address the shared inflammatory pathways.

Main Methods:

  • Review of existing literature on the relationship between COPD and T2DM.
  • Analysis of the impact of comorbid conditions on disease progression and treatment.
  • Examination of shared inflammatory mechanisms as therapeutic targets.

Main Results:

  • A complex interplay exists between COPD, T2DM, infection risk, and acute exacerbations (AECOPDs), forming a potential vicious cycle.
  • Targeting shared inflammatory substrates is identified as a key strategy for simultaneous treatment.
  • Effective glycemic control is crucial as diabetes-related lung function decline can lower the threshold for COPD manifestation.

Conclusions:

  • Simultaneous management of COPD and T2DM requires careful consideration of drug interactions and disease-specific risks.
  • Interfering with shared inflammatory pathways presents a promising approach for integrated treatment.
  • Prioritizing glycemic control is essential to mitigate the impact of diabetes on lung function and COPD severity.