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Age-Related COVID-19 Influence on Male Fertility
Anastasiia D Shcherbitskaia1, Evgeniia M Komarova1, Yulia P Milyutina1
1D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine, 199034 St. Petersburg, Russia.
International Journal of Molecular Sciences
|November 14, 2023
Summary
Coronavirus infection impacts male reproductive health, with effects varying by age. Younger men showed reduced sperm binding ability, while older men experienced increased DNA fragmentation and inflammation markers post-infection.
Area of Science:
- Reproductive Medicine
- Immunology
- Virology
Background:
- Coronavirus infection has raised concerns regarding male reproductive health.
- Previous studies indicated potential impacts on sperm parameters and testicular inflammation.
Purpose of the Study:
- To investigate age-related changes in male reproductive health following coronavirus infection.
- To assess semen quality, cytokine profiles, and oxidative stress markers in relation to age.
Main Methods:
- Assessed semen parameters, cytokines, and pro/antioxidant markers in 60 post-coronavirus patients and 77 controls.
- Stratified participants into age groups: <35 years and ≥35 years.
- Analyzed data five to seven months after infection.
Main Results:
- Men <35 years: increased round cells, reduced sperm hyaluronan binding, decreased zinc, lower nitrotyrosine.
- Men ≥35 years: increased sperm DNA fragmentation, reduced antioxidant capacity, elevated IL-1β and IL-10.
- IL-1β levels decreased over time post-recovery in all infected patients.
Conclusions:
- Coronavirus infection can adversely affect male reproductive health.
- The impact of coronavirus on male fertility is age-dependent.
- Further research is warranted to understand long-term reproductive consequences.
Keywords:
COVID-19DNA fragmentationcytokinemale fertilitynitrotyrosinesemen qualityspermtotal antioxidant capacityzincMore Related Videos
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